Shares of Sarepta Therapeutics (SRPT) have gotten crushed today after the FDA offered a negative take on Sarepta’s Duchenne muscular dystrophy drug. In fact, Leerink’s Joseph Schwartz and team contend that Sarepta’s “dystrophin argument strongly challenged and largely invalidated by the FDA.” They explain:
Andrew Harnik/Associated Press
The updated FDA review is even more negative on the historical control data. 4-yr. clinical effectiveness data submitted in January at the time was considered as major amendment to eteplirsen NDA that had resulted in the 3-mos. delay in PDUFA action date. Having had multiple months to review this additional submission, the FDA has become even more critical by identifying many potential confounding factors, including two matched historical control patients that were reported to have lost ambulation but also had 10m walk test values reported as well as a secondary analysis showing that when 6MWT scores are plotted based on patient age (rather than years of treatment) that there is substantial overlap between eteplirsen-treated patients and the control group.
Best Value Stocks To Watch For 2019: Digital Realty Trust Inc.(DLR)
- [By Lisa Levin]
DuPont Fabros Technology, Inc. (NYSE: DFT) shares shot up 10 percent to $61.07. Digital Realty Trust, Inc. (NYSE: DLR) announced plans to merge with DuPont Fabros.
- [By Benzinga News Desk]
Last year was brutal for hedge fund investors — but you wouldn’t know it from the fund managers’ paychecks: Link
The MBA’s index of mortgage application activity for the latest week is schedule for release at 7:00 a.m. ET.
The Energy Information Administration’s weekly report on petroleum inventories in the U.S. will be released at 10:30 a.m. ET.
Jefferies Upgraded ConocoPhillips (NYSE: COP) from Hold to Buy
JPMorgan Upgraded Clovis Oncology (NASDAQ: CLVS) From Neutral to Overweight
Morgan Stanley Upgrades TJX Companies (NYSE: TJX) From Equal-Weight to Overweight
Macquarie Downgraded Disney (NYSE: DIS) from Outperform to Neutral
Deutsche Bank Downgraded AvalonBay (NYSE: AVB) from Buy to Hold
Wells Fargo Downgrades Digital Realty Trust (NYSE: DLR) From Outperform To Market Perform
This is a tool used by the Benzinga News Desk each trading day — it's a look at everything happening in the market, in five minutes. To get the full version of this note every morning, click here or email firstname.lastname@example.org.
Best Value Stocks To Watch For 2019: American Capital Agency Corp.(AGNC)
- [By Amanda Alix]
This development will likely give battered mREITs like Annaly Capital (NYSE: NLY ) , Armour Residential (NYSE: ARR ) , and American Capital Agency (NASDAQ: AGNC ) a huge boost as investors begin to feel less panic regarding a tapering of the current QE3 program. Markets have responded to the Summers announcement by soaring skyward, apparently feeling relief and confidence about the fate of the taper.
- [By Amanda Alix]
It was just about one year ago that QE3 made its debut, and mortgage REITs, particularly agency-only players like Annaly Capital (NYSE: NLY ) , Armour Residential (NYSE: ARR ) , and American Capital Agency (NASDAQ: AGNC ) began moaning about the increased competition for mortgage-backed securities guaranteed by Fannie Mae and Freddie Mac.
- [By Boniface Murigu]
It’s no secret that mREITs such as American Capital Agency (NASDAQ: AGNC ) (NASDAQ: AGNC ) (NASDAQ: AGNC ) , Annaly Capital Management (NYSE: NLY ) (NYSE: NLY ) (NYSE: NLY ) ,and CYS Investmentshave gone through a very turbulent trading period, with all major players losing a sizable share of market value.
Best Value Stocks To Watch For 2019: Inter Parfums, Inc.(IPAR)
- [By Monica Gerson]
Inter Parfums, Inc. (NASDAQ: IPAR) is estimated to post its quarterly earnings at $0.31 per share on revenue of $110.58 million.
Norwegian Cruise Line Holdings Ltd (NASDAQ: NCLH) is expected to report its quarterly earnings at $0.37 per share on revenue of $1.10 billion.
Best Value Stocks To Watch For 2019: Seadrill Limited(SDRL)
- [By Paul Ausick]
Seadrill Ltd. (NYSE: SDRL) dropped about 61% Tuesday to post a new 52-week low of $0.65 after closing at $1.67 on Monday. The stock’s 52-week high is $5.21. Volume was more than 5 times the daily average of around 14 million shares. The offshore drilling company warned this morning that it faces “substantial ” losses as bankruptcy proceedings loom.
- [By WWW.THESTREET.COM]
Shares of Seadrill (SDRL) were gaining by 12.46% to 91 cents in pre-market trading on Tuesday morning, after the offshore drilling contract provider said its subsidiary, North Atlantic Drilling, has secured a new 10 year contract.
- [By Chris Lange]
Seadrill Ltd. (NYSE: SDRL) will to share its latest quarterly earnings on Tuesday. The consensus estimates call for $0.22 in EPS and $721.81 million in revenue. Shares were at $2.35 in Friday trading, in a 52-week range of $1.57 to $7.49. The consensus price target is $1.96.
- [By Paul Ausick]
SeaDrill Ltd. (NYSE: SDRL) dropped about 27.5% on Friday to record a new 52-week low of $1.21 against a high of $7.49. The stock closed at $1.67 on Thursday. Volume was more than double the daily average of around 14 million shares. The company had no specific news Friday.